2018-07-11 : 2017 Activity Report
Discover the first edition of the IGBMC activity report, a new annual meeting that will allow everyone to follow in a synthetic way the main lines of our research and our evolution!
2018-07-04 : Transcription defects related to the XPC factor implicated in the disease of children of the moon
Children of the moon cannot be exposed to the sun because of their deficiency in DNA repair proteins including XPC, the factor that recognizes ultraviolet damage. However, this failure is not enough to explain all their symptoms. In this study, researchers from Frédéric Coin's team, including Nicolas Le May, (CNRS / Inserm / University of Strasbourg) showed that the XPC factor was also involved in a fundamental mechanism of gene expression, transcription. These results are published on July 4, 2018 in the journal Nature Communications.
2018-06-01 : Identification of MOSPD2, a novel molecular velcro bridging cellular organelles with the endoplasmic reticulum
Membrane contact sites are newly identified cellular structures that facilitate the communication and molecular exchanges between the different organelles of the cell. A study carried out by Catherine Tomasetto's team characterized a new protein called MOtile SPerm Domain-containing protein 2 (MOSPD2), which mediates the formation of contact sites between the endoplasmic reticulum and other cellular organeles such as endosomes, mitochondria and the Golgi apparatus. These results are published on June 1st 2018 in EMBO reports.
2018-04-13 : Transcription and intellectual disability: a mutation resulting in the almost complete loss of a general transcription factor has a much less severe effect than expected
The transcription is an essential mechanism for gene expression and is regulated by many protein factors. In humans, the TFIID factor, composed of the TATA box binding protein and 13 associated factors (TAFs: TBP-associated factors), is crucial to the initiation of transcription by RNA polymerase II. In this study, Laszlo Tora’s team at the IGBMC (CNRS, Inserm and University of Strasbourg) associated with American, British and Australian collaborators studied the consequences of a mutation in the gene coding for one of the associated factors, the TAF8 protein, in a child with an intellectual disability. Although this mutation causes an almost complete loss of TAF8, the researchers showed that it did not affect the overall transcription, contrary to what is observed after total inactivation of the TAF8 gene in mice. These results were published on April 13 in the journal Human Molecular Genetics.
2018-02-20 : Autism: male hormones could increase the prevalence among boys
Boys are affected four times more than girls by certain developmental disorders of the nervous system, such as autism spectrum disorders. However, all the mutations identified on the sex chromosome X do not explain this gender bias. The work of Angélique Quartier, conducted under the direction of Amélie Piton and Jean-Louis Mandel, has shown that male hormones, such as testosterone and its derivatives, by regulating genes important for brain development, some of which are known to be involved in autism spectrum disorders, could increase the susceptibility of boys to developing these disorders. These results are published in Biological Psychiatry on February 8, 2018.
2018-02-07 : The IGBMC International PhD Call is open!
Your application is due to: March 21st noon (Paris time). Please subscribe on: http://phdprogramme.igbmc.fr/
The IGBMC is one of the leading European biomedical centers, offering an exceptional environment for research and training. We commit ourselves to train students in all fields of structural, molecular and cellular biology with relevance for development, physiology and diseases, and expose them to cutting-edge technology. With a vivid scientific life and an international environment, the IGBMC is the perfect place for PhD students to develop their research projects.
IGBMC’s PhD Programme is a three year - intensive training programme developed to prepare the next generation of scientists. During these three years, our PhD students:
Experience the everyday excitement of working in a laboratory in an intellectually stimulating and dynamic environment alongside IGBMC’s top scientists.
Develop an original research project with access to the latest technology developments.
Have the chance to attend numerous first-class seminars given by internationally distinguished scientists and discuss with them.
Participate in lectures and practical courses that will give students an insight into the latest developments in biology or state of the art technologies and to help them prepare the next steps of their career.
Acquire the skills needed to pursue a successful career in biology.
2017-12-29 : Happy New Year 2018
The IGBMC wishes a very happy new year 2018 !
2017-11-14 : Dynamine, a therapeutic target for different myopathies
The regulation of muscular development is a complex process that is not fully understood and in which among others two proteins, amphiphysin and dynamin, are involved. In this study, Jocelyn Laporte's team at IGBMC show that amphiphysin negatively regulates dynamin activity for normal muscle development and, on the other hand, that a reduction in dynamin levels prevents several types of myopathies. These results were published on November 13, 2017, in the Journal of Clinical Investigation.
2017-10-27 : The Graduate School project “Integrative Molecular and Cellular Biology”, selected in the call Programme d’investissements d’avenir
Based on a strategic clustering of Strasbourg assets in molecular and cellular biology from the three laboratories of excellence (LabEx), namely INRT (IGBMC), MitoCross (GMGM, IBMP, IBMC(ARN)) and NetRNA (IBMC (ARN, RIDI), IBMP), and with the support of cutting-edge technological tools such as the four national infrastructures in health biology (INBS) CELPHEDIA/PHENOMIN, FRISBI, France Génomique and Ingestem, together with the equipment of excellence (EquipEx) I2MC, the Graduate School (EUR) Integrative Molecular and Cellular Biology (IMCBio) project was selected on Tuesday, October 24, as part of the Programme d’investissements d’avenir (PIA3). This unprecedented training project is one of the four EUR winners supported by the University of Strasbourg, which has been allocated €25,717,000 for all of these projects.
2017-02-16 : Introduction to NGS data analysis – 28-29th of September and 2nd of October 2017 (Training)
The platform together with the CNRS organizes a 3-days training presenting an “Introduction to Next Generation Sequencing data analysis”. The training will be held at the CNRS Cronenbourg campus on the 28-29th of September and 2nd of October 2017 (for English speakers).
2017-02-16 : New web tool to filter/extract your variants of interest (DNA-seq)
The platform has recently acquired a new web application to visualize, sort and filter DNA-seq data : PolyWeb™ (© Université Paris Descartes / IHU Imagine – all rights reserved). For more information, don’t hesitate to contact us.